Controllable microfluidic synthesis of multiphase drug-carrying lipospheres for site-targeted therapy

Nanogels as a Chemically Controllable Platform for Targeted Drug Delivery

Synthesis of Functional Materials by Non-Newtonian Microfluidic Multiphase System

With increasing level of polymer solution involvement in multiphase microdevice for for‐ mation of emulsion and fabrication of functional materials, it is of paramount importance to systematically understand the relevant physics of droplet formation in non-Newtonian fluids and how the material formation process may be affected due to the complex rheo‐ logical effect. The chapter aims to review ...

Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy.

Taking a nanoparticle (NP) from discovery to clinical translation has been slow compared to small molecules, in part by the lack of systems that enable their precise engineering and rapid optimization. In this work we have developed a microfluidic platform for the rapid, combinatorial synthesis and optimization of NPs. The system takes in a number of NP precursors from which a library of NPs wi...

Pharmacy-on-a-chip: Microfluidic Synthesis of Pegylated and Folate Receptor-targeted Liposomes for Drug Delivery

This study demonstrates the extension of a formerly established microfluidic hydrodynamic focusing technique for the production of small, nearly monodisperse liposomes toward the continuous-flow synthesis of PEGand PEG-folatemodified liposomes for drug delivery applications via controlled laminar flow in thermoplastic microfluidic devices. These liposomes have been used to investigate the relat...

Design, Synthesis and Biological Evaluation of Ketoprofen Conjugated To RGD/NGR for Targeted Cancer Therapy

It is well known that Arginine-Glycine-Aspartic acid (RGD) and Asparagine-Glycine-Arginine (NGR) peptides preferentially bind to integrin receptors and aminopeptidase Nrespectively and these two receptors play important roles in angiogenesis. Therefore ketoprofenas a non-selective cox Inhibitor was conjugated with linear RGD and NGR to take advantageof targeting capability of these two motifs a...